Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are hallmark features of inflammatory airway diseases, including asthma. Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...

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Bibliografische gegevens
Hoofdauteurs: Huang, Fen, Zhang, Hongkang, Wu, Meng, Yang, Huanghe, Kudo, Makoto, Peters, Christian J., Woodruff, Prescott G., Solberg, Owen D., Donne, Matthew L., Huang, Xiaozhu, Sheppard, Dean, Fahy, John V., Wolters, Paul J., Hogan, Brigid L. M., Finkbeiner, Walter E., Li, Min, Jan, Yuh-Nung, Jan, Lily Yeh, Rock, Jason R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479591/
https://ncbi.nlm.nih.gov/pubmed/22988107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214596109
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