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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

Lymphatic dissemination from the primary tumor is a major mechanism by which breast cancer cells access the systemic circulation, resulting in distant metastasis and mortality. Numerous studies link activation of hypoxia-inducible factor 1 (HIF-1) with tumor angiogenesis, metastasis, and patient mor...

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Bibliographische Detailangaben
Hauptverfasser: Schito, Luana, Rey, Sergio, Tafani, Marco, Zhang, Huafeng, Wong, Carmen Chak-Lui, Russo, Andrea, Russo, Matteo A., Semenza, Gregg L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479586/
https://ncbi.nlm.nih.gov/pubmed/23012449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214019109
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