Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

The proteins MDM2 and MDM4 are key negative regulators of the tumor suppressor protein p53, which are frequently upregulated in cancer cells. They inhibit the transactivation activity of p53 by binding separately or in concert to its transactivation domain. MDM2 is also a ubiquitin ligase that leads...

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Bibliographic Details
Main Authors: Vogel, Simon M., Bauer, Matthias R., Joerger, Andreas C., Wilcken, Rainer, Brandt, Tobias, Veprintsev, Dmitry B., Rutherford, Trevor J., Fersht, Alan R., Boeckler, Frank M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479485/
https://ncbi.nlm.nih.gov/pubmed/23035244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215060109
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