Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation

Protein kinase A (PKA) is activated during sympathetic stimulation of the heart and phosphorylates key proteins involved in cardiac Ca(2+) handling, including the L-type Ca(2+) channel (Ca(V)1.2) and phospholamban (PLN). This results in acceleration and amplification of the beat-to-beat changes in c...

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Bibliografski detalji
Glavni autori: Jones, Brian W., Brunet, Sylvain, Gilbert, Merle L., Nichols, C. Blake, Su, Thomas, Westenbroek, Ruth E., Scott, John D., Catterall, William A., McKnight, G. Stanley
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479465/
https://ncbi.nlm.nih.gov/pubmed/23035250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215219109
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