EPR oxygen imaging and hyperpolarized (13)C MRI of pyruvate metabolism as non-invasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate

The hypoxic nature of tumors results in treatment resistance and poor prognosis. To spare limited oxygen for more crucial pathways, hypoxic cancerous cells suppress mitochondrial oxidative phosphorylation, and promote glycolysis for energy production. Thereby, inhibition of glycolysis has the potent...

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Autori principali: Matsumoto, Shingo, Saito, Keita, Yasui, Hironobu, Morris, H. Douglas, Munasinghe, Jeeva P., Lizak, Martin, Merkle, Hellmut, Ardenkjaer-Larsen, Jan Henrik, Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Koretsky, Alan P., Mitchell, James B., Krishna, Murali C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479339/
https://ncbi.nlm.nih.gov/pubmed/22692861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.24355
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