EPR oxygen imaging and hyperpolarized (13)C MRI of pyruvate metabolism as non-invasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate

The hypoxic nature of tumors results in treatment resistance and poor prognosis. To spare limited oxygen for more crucial pathways, hypoxic cancerous cells suppress mitochondrial oxidative phosphorylation, and promote glycolysis for energy production. Thereby, inhibition of glycolysis has the potent...

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Huvudupphovsmän: Matsumoto, Shingo, Saito, Keita, Yasui, Hironobu, Morris, H. Douglas, Munasinghe, Jeeva P., Lizak, Martin, Merkle, Hellmut, Ardenkjaer-Larsen, Jan Henrik, Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Koretsky, Alan P., Mitchell, James B., Krishna, Murali C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479339/
https://ncbi.nlm.nih.gov/pubmed/22692861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.24355
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