4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug resistance transporter

[Image: see text] The 4-Isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, inc...

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Main Authors: Hulubei, Victoria, Meikrantz, Scott B., Quincy, David A., Houle, Tina, McKenna, John I, Rogers, Mark E., Steiger, Scott, Natale, N.R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479305/
https://ncbi.nlm.nih.gov/pubmed/23063517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.09.022
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