Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

BACKGROUND: The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighboring cells and induce the propagation of neurodegeneration. RESULTS: In this stu...

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Detalhes bibliográficos
Main Authors: Konno, Masatoshi, Hasegawa, Takafumi, Baba, Toru, Miura, Emiko, Sugeno, Naoto, Kikuchi, Akio, Fiesel, Fabienne C, Sasaki, Tsutomu, Aoki, Masashi, Itoyama, Yasuto, Takeda, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479026/
https://ncbi.nlm.nih.gov/pubmed/22892036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-38
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