The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

Many neurodegenerative diseases share a common pathological feature: the deposition of amyloid-like fibrils composed of misfolded proteins. Emerging evidence suggests that these proteins may spread from cell-to-cell and encourage the propagation of neurodegeneration in a prion-like manner. Here, we...

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Main Authors: Hasegawa, Takafumi, Konno, Masatoshi, Baba, Toru, Sugeno, Naoto, Kikuchi, Akio, Kobayashi, Michiko, Miura, Emiko, Tanaka, Nobuyuki, Tamai, Keiichi, Furukawa, Katsutoshi, Arai, Hiroyuki, Mori, Fumiaki, Wakabayashi, Koichi, Aoki, Masashi, Itoyama, Yasuto, Takeda, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245276/
https://ncbi.nlm.nih.gov/pubmed/22216284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029460
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