A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

Antibody diversification requires the DNA deaminase AID to induce DNA instability at immunoglobulin (Ig) loci upon B cell stimulation. For efficient cytosine deamination, AID requires single-stranded DNA and needs to gain access to Ig loci, with RNA pol II transcription possibly providing both aspec...

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Auteurs principaux: Willmann, Katharina L., Milosevic, Sara, Pauklin, Siim, Schmitz, Kerstin-Maike, Rangam, Gopinath, Simon, Maria T., Maslen, Sarah, Skehel, Mark, Robert, Isabelle, Heyer, Vincent, Schiavo, Ebe, Reina-San-Martin, Bernardo, Petersen-Mahrt, Svend K.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478926/
https://ncbi.nlm.nih.gov/pubmed/23008333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112145
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