Targeting Mannose Binding Lectin Confers Long Lasting Protection with a Surprisingly Wide Therapeutic Window in Cerebral Ischemia

BACKGROUND: The involvement of complement system in brain injury has been scarcely investigated. Here we document the pivotal role of mannose binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic injury. METHODS AND RESULTS: Focal cerebral ischemi...

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Main Authors: Orsini, Franca, Villa, Pia, Parrella, Sara, Zangari, Rosalia, Zanier, Elisa R., Gesuete, Raffaella, Stravalaci, Matteo, Fumagalli, Stefano, Ottria, Roberta, Reina, Josè J., Paladini, Alessandra, Micotti, Edoardo, Ribeiro-Viana, Renato, Rojo, Javier, Pavlov, Vasile I., Stahl, Gregory L., Bernardi, Anna, Gobbi, Marco, De Simoni, Maria-Grazia
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478764/
https://ncbi.nlm.nih.gov/pubmed/22879370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.103051
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