Targeting Mannose Binding Lectin Confers Long Lasting Protection with a Surprisingly Wide Therapeutic Window in Cerebral Ischemia

BACKGROUND: The involvement of complement system in brain injury has been scarcely investigated. Here we document the pivotal role of mannose binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic injury. METHODS AND RESULTS: Focal cerebral ischemi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Orsini, Franca, Villa, Pia, Parrella, Sara, Zangari, Rosalia, Zanier, Elisa R., Gesuete, Raffaella, Stravalaci, Matteo, Fumagalli, Stefano, Ottria, Roberta, Reina, Josè J., Paladini, Alessandra, Micotti, Edoardo, Ribeiro-Viana, Renato, Rojo, Javier, Pavlov, Vasile I., Stahl, Gregory L., Bernardi, Anna, Gobbi, Marco, De Simoni, Maria-Grazia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478764/
https://ncbi.nlm.nih.gov/pubmed/22879370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.103051
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