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Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing
Forward genetic screens in zebrafish have identified >9000 mutants, many of which are potential disease models. Most mutants remain molecularly uncharacterized because of the high cost, time and labor investment required for positional cloning. These costs limit the benefit of previous genetic sc...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Company of Biologists
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478692/ https://ncbi.nlm.nih.gov/pubmed/23052906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.083931 |
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