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Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing
Forward genetic screens in zebrafish have identified >9000 mutants, many of which are potential disease models. Most mutants remain molecularly uncharacterized because of the high cost, time and labor investment required for positional cloning. These costs limit the benefit of previous genetic sc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478692/ https://ncbi.nlm.nih.gov/pubmed/23052906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.083931 |
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