Sequence-dependent sliding kinetics of p53

Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while simultaneously reading its sequence can accelerate TF’s location of target si...

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Bibliographische Detailangaben
Hauptverfasser: Leith, Jason S., Tafvizi, Anahita, Huang, Fang, Uspal, William E., Doyle, Patrick S., Fersht, Alan R., Mirny, Leonid A., van Oijen, Antoine M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478643/
https://ncbi.nlm.nih.gov/pubmed/23012405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120452109
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