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Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer

Transcriptional regulation of the Hedgehog (HH) signaling response is mediated by GLI genes (GLI1, GLI2) downstream of SMO, that are also activated by oncogenic signaling pathways. We have demonstrated the importance of targeting GLI downstream of SMO in the induction of cell death in human colon ca...

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書誌詳細
主要な著者: Agyeman, Akwasi, Mazumdar, Tapati, Houghton, Janet A.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478462/
https://ncbi.nlm.nih.gov/pubmed/23097684
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