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Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells

Canonical Hedgehog (HH) signaling is characterized by Smoothened (Smo)-dependent activation of the transcription factors Gli1 and Gli2, which regulate HH target genes. In human colon carcinoma cells, treatment with the Gli small molecule inhibitor GANT61 induces extensive cell death, in contrast to...

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Main Authors: Mazumdar, Tapati, DeVecchio, Jennifer, Agyeman, Akwasi, Shi, Ting, Houghton, Janet A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165104/
https://ncbi.nlm.nih.gov/pubmed/21747117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4173
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