CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

Here, we investigated the compartment-specific role of cell cycle arrest and senescence in breast cancer tumor growth. For this purpose, we generated a number of hTERT-immortalized senescent fibroblast cell lines overexpressing CDK inhibitors, such as p16(INK4A), p19(ARF) or p21(WAF1/CIP1). Interest...

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Detalhes bibliográficos
Main Authors: Capparelli, Claudia, Chiavarina, Barbara, Whitaker-Menezes, Diana, Pestell, Timothy G., Pestell, Richard G., Hulit, James, Andò, Sebastiano, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478311/
https://ncbi.nlm.nih.gov/pubmed/22935696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21884
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