Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor

Activation of FFA1 (GPR40), a member of G protein-coupling receptor family A, is mediated by medium- and long-chain fatty acids and leads to amplification of glucose-stimulated insulin secretion, suggesting a potential role for free fatty acid 1 (FFA1) as a target for type 2 diabetes. It was assumed...

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Main Authors: Lin, Daniel C.-H., Guo, Qi, Luo, Jian, Zhang, Jane, Nguyen, Kathy, Chen, Michael, Tran, Thanh, Dransfield, Paul J., Brown, Sean P., Houze, Jonathan, Vimolratana, Marc, Jiao, Xian Yun, Wang, Yingcai, Birdsall, Nigel J. M., Swaminath, Gayathri
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477236/
https://ncbi.nlm.nih.gov/pubmed/22859723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.079640
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