Epithelial Mesenchymal Transition and Pancreatic Tumor Initiating CD44+/EpCAM+ Cells Are Inhibited by γ-Secretase Inhibitor IX

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high rate of metastasis. Recent studies have indicated that the Notch signalling pathway is important in PDAC initiation and maintenance, although the specific cell biological roles of the pathway remain to be established. Here...

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Main Authors: Palagani, Vindhya, El Khatib, Mona, Kossatz, Uta, Bozko, Przemyslaw, Müller, Martin R., Manns, Michael P., Krech, Till, Malek, Nisar P., Plentz, Ruben R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477166/
https://ncbi.nlm.nih.gov/pubmed/23094026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046514
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