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Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody
BACKGROUND: HER2 plays a critical role in the pathogenesis of many cancers and is linked to poor prognosis or cancer metastases. Monoclonal antibodies, such as Herceptin against HER2-overexpressing cancers, have showed satisfactory clinical therapeutic effect. However, they have difficulty to surmou...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477046/ https://ncbi.nlm.nih.gov/pubmed/22748113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-336 |
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