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ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation

Following amino acid deprivation, the amino acid response (AAR) induces transcription from specific genes through a collection of signaling mechanisms, including the GCN2-eIF2-ATF4 pathway. The present report documents that the histone demethylase JMJD3 is an activating transcription factor 4 (ATF4)...

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Bibliografski detalji
Glavni autori: Shan, Jixiu, Fu, Lingchen, Balasubramanian, Mukundh N., Anthony, Tracy, Kilberg, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476305/
https://ncbi.nlm.nih.gov/pubmed/22955275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399600
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