A Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK)-dependent Transcriptional Program Controls Activation of the Early Growth Response 1 (EGR1) Gene during Amino Acid Limitation

Amino acid (AA) limitation in mammalian cells triggers a collection of signaling cascades jointly referred to as the AA response (AAR). In human HepG2 hepatocellular carcinoma, the early growth response 1 (EGR1) gene was induced by either AA deprivation or endoplasmic reticulum stress. AAR-dependent...

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Detalhes bibliográficos
Main Authors: Shan, Jixiu, Balasubramanian, Mukundh N., Donelan, William, Fu, Lingchen, Hayner, Jaclyn, Lopez, Maria-Cecilia, Baker, Henry V., Kilberg, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148889/
https://ncbi.nlm.nih.gov/pubmed/25028509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565028
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