Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity

Lubricin (or proteoglycan 4 (PRG4)) is an abundant mucin-like glycoprotein in synovial fluid (SF) and a major component responsible for joint lubrication. In this study, it was shown that O-linked core 2 oligosaccharides (Galβ1–3(GlcNAcβ1–6)GalNAcα1-Thr/Ser) on lubricin isolated from rheumatoid arth...

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Hlavní autoři: Jin, Chunsheng, Ekwall, Anna-Karin Hultgård, Bylund, Johan, Björkman, Lena, Estrella, Ruby P., Whitelock, John M., Eisler, Thomas, Bokarewa, Maria, Karlsson, Niclas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476260/
https://ncbi.nlm.nih.gov/pubmed/22930755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363119
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