Extracellular Matrix Lumican Promotes Bacterial Phagocytosis, and Lum(−/−) Mice Show Increased Pseudomonas aeruginosa Lung Infection Severity

Phagocytosis is central to bacterial clearance, but the exact mechanism is incompletely understood. Here, we show a novel and critical role for lumican, the connective tissue extracellular matrix small leucine-rich repeat proteoglycan, in CD14-mediated bacterial phagocytosis. In Psuedomonas aerugino...

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Bibliografiske detaljer
Main Authors: Shao, HanJuan, Lee, Seakwoo, Gae-Scott, Sherri, Nakata, Chiaki, Chen, Shoujun, Hamad, Abdel R., Chakravarti, Shukti
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476255/
https://ncbi.nlm.nih.gov/pubmed/22865855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380550
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