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Extracellular Matrix Lumican Promotes Bacterial Phagocytosis, and Lum(−/−) Mice Show Increased Pseudomonas aeruginosa Lung Infection Severity
Phagocytosis is central to bacterial clearance, but the exact mechanism is incompletely understood. Here, we show a novel and critical role for lumican, the connective tissue extracellular matrix small leucine-rich repeat proteoglycan, in CD14-mediated bacterial phagocytosis. In Psuedomonas aerugino...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476255/ https://ncbi.nlm.nih.gov/pubmed/22865855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380550 |
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