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Extracellular Matrix Protein Lumican Promotes Clearance and Resolution of Pseudomonas aeruginosa Keratitis in a Mouse Model
Lumican is an extracellular protein that associates with CD14 on the surface of macrophages and neutrophils, and promotes CD14-TLR4 mediated response to bacterial lipopolysaccharides (LPS). Lumican-deficient (Lum (−/−)) mice and macrophages are impaired in TLR4 signals; raising the possibility that...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554612/ https://ncbi.nlm.nih.gov/pubmed/23358433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054765 |
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