Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry

Phosporothioate oligonucleotides represent an important class of therapeutic oligonucleotides, in which none-bridging oxygen atoms of the phosphate groups are replaced by sulfur. These oligonucleotides are designed to treat disease by modulating gene expression of an affected individual. As the deve...

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Bibliografiske detaljer
Main Authors: Erb, Robert, Leithner, Katharina, Bernkop-Schnürch, Andreas, Oberacher, Herbert
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475866/
https://ncbi.nlm.nih.gov/pubmed/22806756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9381-2
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