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DETECTING LOW-LEVEL SYNTHESIS IMPURITIES IN MODIFIED PHOSPHOROTHIOATE OLIGONUCLEOTIDES USING LIQUID CHROMATOGRAPHY – HIGH RESOLUTION MASS SPECTROMETRY
An LC-MS method based on the use of high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTIRCMS) for profiling oligonucleotides synthesis impurities is described. [Image: see text] Oligonucleotide phosphorothioatediesters (phosphorothioate oligonucleotides), in which one of...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3146765/ https://ncbi.nlm.nih.gov/pubmed/21811394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.06.001 |
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