DETECTING LOW-LEVEL SYNTHESIS IMPURITIES IN MODIFIED PHOSPHOROTHIOATE OLIGONUCLEOTIDES USING LIQUID CHROMATOGRAPHY – HIGH RESOLUTION MASS SPECTROMETRY

An LC-MS method based on the use of high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTIRCMS) for profiling oligonucleotides synthesis impurities is described. [Image: see text] Oligonucleotide phosphorothioatediesters (phosphorothioate oligonucleotides), in which one of...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Nikcevic, Irena, Wyrzykiewicz, Tadeusz K., Limbach, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146765/
https://ncbi.nlm.nih.gov/pubmed/21811394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.06.001
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares