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Oral Immunization of Dogs with Purified Cholera Toxin, Crude Cholera Toxin, or B Subunit: Evidence for Synergistic Protection by Antitoxic and Antibacterial Mechanisms

The immunogenicity and safety of purified cholera toxin (CT), its B subunit, and a crude culture filtrate of toxigenic Vibrio cholerae (CrT) were compared in dogs immunized orally and challenged with virulent V. cholerae. CT and CrT caused marked protection in two- or three-dose regimens. Protection...

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Detalhes bibliográficos
Publicado no:Infect Immun
Principais autores: Pierce, Nathaniel F., Cray, William C., Sacci, John B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1982
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347586/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6889574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.37.2.687-694.1982
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