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Oral Immunization of Dogs with Purified Cholera Toxin, Crude Cholera Toxin, or B Subunit: Evidence for Synergistic Protection by Antitoxic and Antibacterial Mechanisms

The immunogenicity and safety of purified cholera toxin (CT), its B subunit, and a crude culture filtrate of toxigenic Vibrio cholerae (CrT) were compared in dogs immunized orally and challenged with virulent V. cholerae. CT and CrT caused marked protection in two- or three-dose regimens. Protection...

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Hlavní autoři: Pierce, Nathaniel F., Cray, William C., Sacci, John B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1982
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC347586/
https://ncbi.nlm.nih.gov/pubmed/6889574
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