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A Solute's Perspective on How TMAO, Urea and GdnHCl Affect Water's Hydrogen Bonding Ability

While the thermodynamic effects of trimethylamine oxide (TMAO), urea and guanidine hydrochloride (GdnHCl) on protein stability are well understood, the underlying mechanisms of action are less well characterized and, in some cases, even under debate. Herein, we employ the stretching vibration of two...

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Detalhes bibliográficos
Main Authors: Pazos, Ileana M., Gai, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475735/
https://ncbi.nlm.nih.gov/pubmed/22998405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp307414s
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