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Long-Timescale Molecular Dynamics Simulations Elucidate the Dynamics and Kinetics of Exposure of the Hydrophobic Patch in Troponin C

Troponin (Tn) is an important regulatory protein in the thin-filament complex of cardiomyocytes. Calcium binding to the troponin C (TnC) subunit causes a change in its dynamics that leads to the transient opening of a hydrophobic patch on TnC’s surface, to which a helix of another subunit, troponin...

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Bibliografski detalji
Glavni autori: Lindert, Steffen, Kekenes-Huskey, Peter M., McCammon, J. Andrew
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475331/
https://ncbi.nlm.nih.gov/pubmed/23083722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.08.058
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