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Inhibition of osteoclastogenesis by RNA interference targeting RANK

BACKGROUND: Osteoclasts and osteoblasts regulate bone resorption and formation to allow bone remodeling and homeostasis. The balance between bone resorption and formation is disturbed by abnormal recruitment of osteoclasts. Osteoclast differentiation is dependent on the receptor activator of nuclear...

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Autors principals: Ma, Ruofan, Xu, Jie, Dong, Bin, Kauther, Max Daniel, Jäger, Marcus, Wedemeyer, Christian
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475138/
https://ncbi.nlm.nih.gov/pubmed/22913338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-13-154
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