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Inhibition of osteoclastogenesis by RNA interference targeting RANK

BACKGROUND: Osteoclasts and osteoblasts regulate bone resorption and formation to allow bone remodeling and homeostasis. The balance between bone resorption and formation is disturbed by abnormal recruitment of osteoclasts. Osteoclast differentiation is dependent on the receptor activator of nuclear...

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Bibliographic Details
Main Authors: Ma, Ruofan, Xu, Jie, Dong, Bin, Kauther, Max Daniel, Jäger, Marcus, Wedemeyer, Christian
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475138/
https://ncbi.nlm.nih.gov/pubmed/22913338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-13-154
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