Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes

BACKGROUND: Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune sys...

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Detalhes bibliográficos
Main Authors: Chauncey, Kassidy M, Lopez, M Cecilia, Sidhu, Gurjit, Szarowicz, Sarah E, Baker, Henry V, Quinn, Conrad, Southwick, Frederick S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475123/
https://ncbi.nlm.nih.gov/pubmed/22747600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-33
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