Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model

Anxiety disorders are characterized by persistent, excessive fear. Therapeutic interventions that reverse deficits in fear extinction represent a tractable approach to treating these disorders. We previously reported that 129S1/SvImJ (S1) mice show no extinction learning following normal fear condit...

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Bibliographic Details
Main Authors: Whittle, Nigel, Schmuckermair, Claudia, Gunduz Cinar, Ozge, Hauschild, Markus, Ferraguti, Francesco, Holmes, Andrew, Singewald, Nicolas
Format: Artigo
Language:Inglês
Published: Pergamon Press 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474950/
https://ncbi.nlm.nih.gov/pubmed/22722028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.06.001
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