Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction

Extinction-based exposure therapy is used to treat anxiety- and trauma-related disorders; however, there is the need to improve its limited efficacy in individuals with impaired fear extinction learning and to promote greater protection against return-of-fear phenomena. Here, using 129S1/SvImJ mice,...

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Bibliographic Details
Published in:Transl Psychiatry
Main Authors: Whittle, N, Maurer, V, Murphy, C, Rainer, J, Bindreither, D, Hauschild, M, Scharinger, A, Oberhauser, M, Keil, T, Brehm, C, Valovka, T, Striessnig, J, Singewald, N
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315560/
https://ncbi.nlm.nih.gov/pubmed/27922638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.231
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