Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPAR γ and RhoA/Rho-kinase

Dominant negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor-γ (PPARγ) cause hypertension by an unknown mechanism. Hypertension and vascular dysfunction are recapitulated by expression of dominant negative PPARγ specifically in vascular smooth muscle of tran...

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Autori principali: Pelham, Christopher J., Ketsawatsomkron, Pimonrat, Groh, Séverine, Grobe, Justin L., de Lange, Willem J., Ibeawuchi, Stella-Rita C., Keen, Henry L., Weatherford, Eric T., Faraci, Frank M., Sigmund, Curt D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474846/
https://ncbi.nlm.nih.gov/pubmed/23040068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.08.011
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