PPARγ Regulates Resistance Vessel Tone Through a Mechanism Involving RGS5-mediated Control of PKC and BKCa Channel Activity

RATIONALE: Activation of peroxisome proliferator-activated receptor-γ (PPARγ) by thiazolidinediones lowers blood pressure, whereas PPARγ mutations cause hypertension. Previous studies suggest these effects may be mediated through the vasculature, but the underlying mechanisms remain unclear. OBJECTI...

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Detalhes bibliográficos
Main Authors: Ketsawatsomkron, Pimonrat, Lorca, Ramón A., Keen, Henry L., Weatherford, Eric T., Liu, Xuebo, Pelham, Christopher J., Grobe, Justin L., Faraci, Frank M., England, Sarah K., Sigmund, Curt D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494760/
https://ncbi.nlm.nih.gov/pubmed/22962432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.271577
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