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Enrichment and Stratification for Predementia Alzheimer Disease Clinical Trials

The tau and amyloid pathobiological processes underlying Alzheimer disease (AD) progresses slowly over periods of decades before clinical manifestation as mild cognitive impairment (MCI), then more rapidly to dementia, and eventually to end-stage organ failure. The failure of clinical trials of cand...

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Autors principals: Holland, Dominic, McEvoy, Linda K., Desikan, Rahul S., Dale, Anders M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474753/
https://ncbi.nlm.nih.gov/pubmed/23082203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047739
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