Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

Mutations in the lamin A/C gene that cause Hutchinson-Gilford progeria syndrome lead to expression of a truncated, permanently farnesylated prelamin A variant called progerin. Blocking farnesylation leads to an improvement in the abnormal nuclear morphology observed in cells expressing progerin, whi...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Yuexia, Ӧstlund, Cecilia, Choi, Jason C., Swayne, Theresa C., Gundersen, Gregg G., Worman, Howard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2012
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474666/
https://ncbi.nlm.nih.gov/pubmed/22895092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.21675
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