The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin Griffithsin

[Image: see text] Griffithsin (GRFT) is a lectin that has been shown to inhibit HIV infection by binding to high mannose glycan structures on the surface of gp120, and is among the most potent HIV entry inhibitors reported so far. However, important biochemical details on the antiviral mechanism of...

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Bibliographic Details
Main Authors: Xue, Jie, Gao, Yongguang, Hoorelbeke, Bart, Kagiampakis, Ioannis, Zhao, Bo, Demeler, Borries, Balzarini, Jan, LiWang, Patricia J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474606/
https://ncbi.nlm.nih.gov/pubmed/22827601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300194b
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