A Phase I Clinical Study of High-Dose Ketoconazole Plus Weekly Docetaxel in Metastatic Castration-Resistant Prostate Cancer

PURPOSE: High-dose ketoconazole and docetaxel have shown activity as single agents against castration-resistant prostate cancer (CRPC). The goal of this phase I study was to determine the maximum tolerated doses, side effects, and pharmacokinetic interaction of coadministered docetaxel and ketoconaz...

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Main Authors: Figg, William D., Woo, Sukyung, Zhu, Wenhui, Chen, Xiaohong, Ajiboye, Atinuke, Steinberg, Seth M., Price, Douglas K., Wright, John J., Parnes, Howard L., Arlen, Philip M., Gulley, James L., Dahut, William L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474294/
https://ncbi.nlm.nih.gov/pubmed/20399458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2010.02.020
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