A Phase I Clinical Study of High-Dose Ketoconazole Plus Weekly Docetaxel in Metastatic Castration-Resistant Prostate Cancer

PURPOSE: High-dose ketoconazole and docetaxel have shown activity as single agents against castration-resistant prostate cancer (CRPC). The goal of this phase I study was to determine the maximum tolerated doses, side effects, and pharmacokinetic interaction of coadministered docetaxel and ketoconaz...

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Bibliografiske detaljer
Main Authors: Figg, William D., Woo, Sukyung, Zhu, Wenhui, Chen, Xiaohong, Ajiboye, Atinuke, Steinberg, Seth M., Price, Douglas K., Wright, John J., Parnes, Howard L., Arlen, Philip M., Gulley, James L., Dahut, William L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474294/
https://ncbi.nlm.nih.gov/pubmed/20399458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2010.02.020
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