Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

Normal human T lymphocytes incubated with adenosine (10 μM) for 30 min at 37°C show an increase in the percentage of cells expressing receptors for the Fc portion of IgG (RFc(γ)) and the OKT8 antigen, while the proportion of OKT4(+) cells decreases. These effects occur exclusively in a subset of T c...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mandler, Raya, Birch, Ruth E., Polmar, Stephen H., Kammer, Gary M., Rudolph, Stephen A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1982
Schlagworte:	Biological Sciences: Medical Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6296838/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.23.7542
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