Dithiolethione Compounds Inhibit Akt Signaling in Human Breast and Lung Cancer Cells by Increasing PP2A Activity

The chemo-preventative effects of dithiolethione compounds are attributed to their activation of anti-oxidant response elements (ARE) by reacting with the Nrf2/Keap1 protein complex. In this study, we demonstrate anti-proliferative effects of the dithiolethione compound ACS-1 in human cancer cell li...

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Bibliographische Detailangaben
Hauptverfasser: Switzer, Christopher H., Ridnour, Lisa A., Cheng, Robert Y.S., Sparatore, Anna, Soldato, Piero Del, Moody, Terry W., Vitek, Michael P., Roberts, David D., Wink, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472634/
https://ncbi.nlm.nih.gov/pubmed/19701246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.244
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