Modulation of Carcinogen Activation and Detoxification by Novel Dithiolethione-Modified NSAIDs in Human Hepatoma HepG2 and Colon LS180 Cells

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are promising chemopreventive agents against colon and other cancers. However the molecular basis mediated by NSAIDs for chemoprevention has not been fully elucidated. Environmental carcinogens induce DNA mutation and cellular transformation; th...

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Autori principali: Bass, Sara E., Sienkiewicz, Pawel, MacDonald, Christopher J., Cheng, Robert Y.S., Sparatore, Anna, Del Soldato, Piero, Roberts, David D., Moody, Terry W., Wink, David A., Yeh, Grace Chao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755634/
https://ncbi.nlm.nih.gov/pubmed/19276279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1870
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