LOSS OF TYPE III TRANSFORMING GROWTH FACTOR BETA RECEPTOR EXPRESSION IS DUE TO METHYLATION SILENCING OF THE TRANSCRIPTION FACTOR GATA3 IN RENAL CELL CARCINOMA

Loss of Transforming Growth Factor β Receptor III (TβRIII) correlates with loss of Transforming Growth Factor β (TGF-β) responsiveness and suggests a role for dysregulated TGF-β signaling in clear cell renal cell carcinoma (ccRCC) progression and metastasis. Here we identify that for all stages of c...

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Detalhes bibliográficos
Main Authors: Cooper, Simon J., Zou, Hongzhi, LeGrand, Shauna N., Marlow, Laura A., von Roemeling, Christina, Radisky, Derek, Wu, Kevin J., Hempel, Nadine, Margulis, Vitaly, Tun, Han, Blobe, Gerard C., Wood, Christopher G., Copland, John A
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472631/
https://ncbi.nlm.nih.gov/pubmed/20208565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.64
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