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Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

Direct chemical modifications of helical peptides have provided a simple and effective means to ‘translate’ the bioactive helical peptides into potential therapeutics targeting intracellular protein-protein interactions. Previously, we have shown that the distance-matching bisaryl cross-linkers can...

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Main Authors: Muppidi, Avinash, Doi, Kenichiro, Edwardraja, Selvakumar, Drake, Eric, Gulick, Andrew M., Wang, Hong-Gang, Lin, Qing
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472523/
https://ncbi.nlm.nih.gov/pubmed/22920569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306864v
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