Adeno-Associated Viral Vectors Based on Serotype 3b Use Components of the Fibroblast Growth Factor Receptor Signaling Complex for Efficient Transduction

Adeno-associated virus type 3b (AAV3b) has been largely ignored by gene therapists because of the inability of vectors based on this serotype to transduce target tissues efficiently. Here we describe a phenomenon unique to AAV3b in that vectors based on this serotype mediate enhanced transduction in...

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Detalhes bibliográficos
Main Authors: Messina, Emily L., Nienaber, Jeffrey, Daneshmand, Mani, Villamizar, Nestor, Samulski, Jude, Milano, Carmelo, Bowles, Dawn E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472518/
https://ncbi.nlm.nih.gov/pubmed/22680698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.066
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